Big Gun Biologic Combo Safe… But Not Any More Effective!

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Rituxan Combined With a TNF Inhibitor and Methotrexate Safe But Not Any More Effective For RA

ScienceDaily reports a recent trial of rituximab in combination with a tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) in patients with active rheumatoid arthritis (RA) found the safety profile to be consistent with other RA trials with TNF inhibitors. While the trial reported no new safety risks, clear evidence of an efficacy advantage in RA patients receiving the combination therapy was not observed in this study sample.  Results of the trial are published in Arthritis & Rheumatism.

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